DOSIMYCO™ Mycophenolic acid in plasma, LC-MS/MS

[products] DOSIMYCO™ Mycophenolic acid in plasma, LC-MS/MS
[products] DOSIMYCO™ Mycophenolic acid in plasma, LC-MS/MS - image 1
[products] DOSIMYCO™ Mycophenolic acid in plasma, LC-MS/MS - image 2

Reagent kit

  • Available for 200 analysis
  • Internal standard with isotope labeled analytes synthesized by Alsachim
  • For LC-MS/MS application
  • The set is ready-to-use with all consumables

DOSIMYCO™ is intendent for research use only, not for diagnostic.

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Description

Recently, LC-MS/MS analysis has been introduced in many laboratories as an alternative technology for TDM (besides Immunoassays). Alsachim developed a reagent kit based on LC-MS/MS analytical method for the quantification of the immunosuppressant drug in plasma: Mycophenolic acid (MPA) and its glucuronide (MPA-G).

The DOSIMYCO™ kit is an in vitro diagnostic device for the rapid and multiplex assay of the immunosuppressant drug for LC/MS, thanks to in-house production of stable isotope-labeled internal standards with deuterium and carbon-13. This ready-to-use kit is also for routine LC-MS/MS analysis of this immunosuppressant in plasma sample.

DOSIMYCO™ is available for 200 analysis RUO 227-40300-58 (Europe) / 227-40300-91 (Japan)

DOSIMYCO is a registered trademark of Alsachim, a Shimadzu Group Company. This page may contain references to products that are not available in your country. This product could be available for research use only depending of your country. Please contact us to check the availability of these products in your country.

Technical Data

Method of analysis: LC/MS/MS
Parameter: Mycophenolic acid and its glucuronide MPA-G
Analysis time: 1.5 min 
Limit of quantification: 
- MPA : < 0.1 mg/L 
- MPA-G : < 1 mg/L
Linearity: 
- MPA : up to 100 mg/L
- MPA-G : up to 500 mg/L
Specimen: in plasma
Storage: Samples can be stored for up to 7 days at +4°C +/-2°C. For longer storage, it is recommended to freeze the sample at -20°C +/-5°C after collection.
Sample preparation:  
- Transfer calibrator or control or human blood sample into a microtube
- Add reconstituted Internal standards pool 
- Add extraction buffer
- Shake and centrifuge
- Extract the supernatant
- Insert in LC/MS/MS and analyze
Injection volume: 0.1–50 µL
Ionisation: ESI positive
MS/MS-Mode: MRM
Comment: DOSIMYCO™ reagent kit is delivered with all documentation required to use properly the product (complete instructions Manual, safety data sheets, quality an analysis certificates, etc.)

Kit Composition

  • Mobile Phase A
  • Mobile Phase B
  • System Cleaning Phase
  • Extraction Buffer
  • Internal Standard Set
  • Calibrator Set
  • Control Set

Options:

  • Tuning Mix labeled and unlabeled.
  • Microtubes.
  • Lc vial set.

Kit components & accessories